Ethanol → Ethyl 2-amino-3-(4-bromophenyl)propanoate

HRID 509082노트

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HRID 509082 반응식
[NH2:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].O=S(Cl)Cl.[CH3:18][CH2:19]O>>[CH2:18]([O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([Br:13])=[CH:11][CH:12]=1)[CH3:19]

참가 물질

4

반응물 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 856814-Bromophenylalanine

생성물 1

HCID 4016808Ethyl 2-amino-3-(4-bromophenyl)propanoate수율 72%

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온도
80 °C

실험 절차

To a solution of 2-amino-3-(4-bromophenyl)propanoic acid (40 g, 164 mmol) in EtOH (100 mL) was added SOCl2 (30 ml, 422 mmol) dropwise at 80° C. The mixture was stirred at 80° C. for 2 hrs. After the solvent was evaporated, the residue was extracted by EA. The combined organic layers were washed with aqueous NaCl, dried by anhydrous Na2SO4, and concentrated in vacuo to afford ethyl-2-amino-3-(4-bromophenyl)propanoate as a yellow liquid (32 g, yield: 72%).

후처리

  1. customAfter the solvent was evaporated
  2. extractionthe residue was extracted by EA
  3. washThe combined organic layers were washed with aqueous NaCl
  4. dry with materialdried by anhydrous Na2SO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-12f89228bd34420f966beb076effc6c4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096549B2

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