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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2-(3,5-Dimethylbiphenyl-4-yl)-4-[1-(tetrahydrofuran-3-yl)methylidene]-cyclopentane-1,3-dione → 2-(3,5-Dimethylbiphenyl-4-yl)-4-(tetrahydrofuran-3-ylmethyl)-cyclopentane-1,3-dione

HRID 509164
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HRID 509164 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:5]=[C:6]([CH3:21])[C:7]=1[CH:8]1[C:12](=[O:13])[C:11](=[CH:14][CH:15]2[CH2:19][CH2:18][O:17][CH2:16]2)[CH2:10][C:9]1=[O:20].[H][H]>CO.[Pd]>[CH3:21][C:6]1[CH:5]=[C:4]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:3]=[C:2]([CH3:1])[C:7]=1[CH:8]1[C:12](=[O:13])[CH:11]([CH2:14][CH:15]2[CH2:19][CH2:18][O:17][CH2:16]2)[CH2:10][C:9]1=[O:20]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 671093232-(3,5-Dimethylbiphenyl-4-yl)-4-[1-(tetrahydrofuran-3-yl)methylidene]-cyclopentane-1,3-dioneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 584814382-(3,5-Dimethylbiphenyl-4-yl)-4-(tetrahydrofuran-3-ylmethyl)-cyclopentane-1,3-dione수율 41.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 2-(3,5-dimethylbiphenyl-4-yl)-4-[1-(tetrahydrofuran-3-yl)methylidene]-cyclopentane-1,3-dione (0.29 g, 0.8 mmol) in methanol (10 ml) is added 10% palladium on carbon (0.06 g), followed by stirring under a 1 bar hydrogen atmosphere for 8 hours. The reaction mixture is then filtered through diatomaceous earth and concentrated to give a crude product which is purified by flash chromatography (hexane/ethyl acetate) to afford 2-(3,5-dimethylbiphenyl-4-yl)-4-(tetrahydrofuran-3ylmethyl)-cyclopentane-1,3-dione (0.12 g).

후처리

  1. filtrationThe reaction mixture is then filtered through diatomaceous earth
  2. concentrationconcentrated
  3. customto give a crude product which
  4. customis purified by flash chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-b1175d9f3ccb424a94656784485f2b83
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09096560B2

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