2-(4-Bromophenyl)-2-phenyloxirane → 2-(4-Bromophenyl)-2-phenylacetaldehyde

HRID 509192노트

반응식

HRID 509192 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:10][O:9]2)=[CH:4][CH:3]=1>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:10]=[O:9])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 157379652-(4-Bromophenyl)-2-phenyloxirane

생성물 1

HCID 125551782-(4-Bromophenyl)-2-phenylacetaldehyde

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 2-(4-bromophenyl)-2-phenyloxirane 51 (5.27 g, 19.15 mmol) and BF3OEt2 (3.29 g, 23.20 mmol) in benzene (50 mL) was shaken vigorously in a separatory funnel for 2 minutes then allowed to stand for 3 minutes. The resulting solution was washed twice with aq. sat. NaHCO3 and the organic layer was separated, dried over Na2SO4 and concentrated to afford 2-(4-bromophenyl)-2-phenylacetaldehyde 52. The crude was used in the next step.

후처리

  1. washThe resulting solution was washed twice with aq. sat. NaHCO3
  2. customthe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a54fb1f46624462e929cf360baaf291a
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096565B2

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