Trifluoroacetic acid → (S)-(4-(Trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methanamine 2,2,2-trifluoroacetate

HRID 509375노트

반응식

HRID 509375 반응식
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C@H:9]([NH:18]C(=O)OC(C)(C)C)[C:10]2[C:15]([CH:16]=[CH2:17])=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:5][CH:4]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[F:31][C:30]([F:33])([F:32])[C:28]([OH:34])=[O:29].[F:27][C:2]([F:1])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([C:10]2[C:15]([CH:16]=[CH2:17])=[CH:14][CH:13]=[CH:12][N:11]=2)[NH2:18])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86687981(S)-tert-butyl ((4-(trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methyl)carbamate

생성물 1

HCID 86687982(S)-(4-(Trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methanamine 2,2,2-trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
23 °C

실험 절차

To a 50 mL round bottom flask containing (S)-tert-butyl ((4-(trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methyl)carbamate (97 mg, 0.256 mmol) was added DCM (3 mL). The resulting mixture was then stirred at 23° C. for 2 min. At this time, TFA was added (3 mL) and the reaction was stirred for 3 h. The solvent was removed, and the material was immediately used with no further purification. MS (ESI pos. ion) m/z: 279.1 (M+1).

후처리

  1. stirringthe reaction was stirred for 3 h
  2. customThe solvent was removed
  3. customthe material was immediately used with no further purification

출처 및 근거

ORD 기록
ord-8518d249bde84fc290fa8bc562bd8ff0
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096527B2

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