Maleic Anhydride → (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

HRID 509570노트

반응식

HRID 509570 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11]N)=[O:10])[CH:6]=[CH:5][N:4]=1.[O:13]1[C:17](=[O:18])[CH:16]=[CH:15][C:14]1=[O:19]>C1COCC1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11][C:17](=[O:18])/[CH:16]=[CH:15]\[C:14]([OH:19])=[O:13])=[O:10])[CH:6]=[CH:5][N:4]=1

참가 물질

4

반응물 2

HCID 7923Maleic AnhydrideHCID 3225512-Methoxyisonicotinohydrazide

생성물 1

HCID 67958827(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of compound 8 (167 mg, 1.0 mmol) in 10 mL of THF was added furan-2,5-dione (110 mg, 1.1 mmol). The mixture was stirred at ambient temperature for 2 hours. After removal of the solvent, the residue was diluted with 10 mL of dichloromethane. The solid was collected by filtration to give (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid 9 as a solid.

후처리

  1. customAfter removal of the solvent
  2. additionthe residue was diluted with 10 mL of dichloromethane
  3. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-1ea406fcc7f647e78ff09f09a921dd3d
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096587B2

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