Triethylamine → 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole

HRID 509685

반응식

HRID 509685 반응식
Cl.[C:2]1([CH3:10])[CH:7]=[CH:6][C:5]([NH:8]N)=[CH:4][CH:3]=1.Br[CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.C(N(CC)CC)C.Cl.[CH3:28][N:29]1[CH2:34][CH2:33][C:32](=O)[CH2:31][CH2:30]1>C(O)C>[CH:14]1([CH2:13][CH2:12][N:8]2[C:5]3[CH:6]=[CH:7][C:2]([CH3:10])=[CH:3][C:4]=3[C:31]3[CH2:30][N:29]([CH3:28])[CH2:34][CH2:33][C:32]2=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 125044-Methylphenylhydrazine monohydrochlorideHCID 15440(2-Bromoethyl)cyclohexaneHCID 122100571-Methylpiperidin-4-one hydrochloride

생성물 1

HCID 578760595-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole수율 16.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Preparation of the title compound was carried out according to General Method 8. p-Tolylhydrazine hydrochloride (500 mg, 3.1 mmol), 1-bromo-2-cyclohexylethane (602 mg, 3 mmol), triethyl amine (303 mg, 3 mmol) and N-methyl-4-piperidone hydrochloride (589 mg, 4.5 mmol) were combined in ethanol (3 ml) to obtain 150 mg of 5-(2-cyclohexylethyl)-2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole after purification on neutral alumina using ethyl acetate-hexane gradient.

출처 및 근거

ORD 기록
ord-931a9033a88b42589e0a518d836758ac
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096591B2

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