Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → chloro-2,3,4,5-tetrahydro-2-methyl-5-(2-morpholinoethyl)-1H-pyrido[4,3-b]indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| 반응물 | 4-(2-Bromoethyl)morpholine | HCID 1502101 | — |
| 반응물 | 1-Methylpiperidin-4-one hydrochloride | HCID 12210057 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | chloro-2,3,4,5-tetrahydro-2-methyl-5-(2-morpholinoethyl)-1H-pyrido[4,3-b]indole | HCID 86634532 | — |
반응 단계
Preparation of the title compound was carried out according to General Method 8. 4-Chlorophenylhydrazine hydrochloride (2 g, 11 mmol), 4-(2-bromoethyl)morpholine (2.1 g, 11 mmol), triethyl amine (4.6 ml, 33 mmol) and N-methyl-4-piperidone hydrochloride (1.6 g, 11 mmol) were combined in ethanol (20 ml) to obtain 180 mg of -chloro-2,3,4,5-tetrahydro-2-methyl-5-(2-morpholinoethyl)-1H-pyrido[4,3-b]indole after purification on silica gel (230-400 mesh) chromatography eluting with acetone-hexane gradient. The free base was converted into its dioxalate salt by treatment of oxalic acid (2 equiv) in anhydrous THF.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096591B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-4b5745504b0a4f48bcf4ec7604e7257e |
| 출처 메모 | uspto-grants-2015_08 |