(5-Fluoro-2-methoxypyridin-3-yl)methanol → 5-Fluoro-2-methoxynicotinaldehyde
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][OH:11])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1>C(OCC)(=O)C.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[O:11])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1참가 물질
4
실험 절차
To (5-fluoro-2-methoxy-pyridin-3-yl)-methanol (36, 8 g, 50.9 mmol) in 300 mL of ethyl acetate, manganese(IV) oxide (39.8 g, 458 mmol) was added and the mixture stirred at room temperature overnight. The reaction mixture was filtered through celite, and the celite bed rinsed with ethyl acetate. The filtrate was concentrated under vacuum, then passed through a plug of silica, eluting with 50% ethyl acetate in heptane to provide the desired compound as a light yellow solid (37, 4.5 g, 29.0 mmol, 57.0% yield).
후처리
- filtrationThe reaction mixture was filtered through celite
- washthe celite bed rinsed with ethyl acetate
- concentrationThe filtrate was concentrated under vacuum
- washeluting with 50% ethyl acetate in heptane
출처 및 근거
- ORD 기록
- ord-973f28eabc2548f0814f563d2ede27d0
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09096593B2
반응 노트
불러오는 중…