Thionyl Chloride → 5-Fluoro-2-methoxy-nicotinoyl chloride

HRID 509999노트

반응식

HRID 509999 반응식
[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:15])=O>>[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([Cl:15])=[O:8]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 404270085-Fluoro-2-methoxynicotinic acid

생성물 1

HCID 582594585-Fluoro-2-methoxy-nicotinoyl chloride

실험 절차

In a round bottom flask, 5-fluoro-2-methoxy-nicotinic acid (150, 250 mg, 1.46 mmol) was combined with thionyl chloride (3.00 mL, 41.1 mmol) and the suspension was stirred at room temperature for 3 hours. The reaction was concentrated to dryness under vacuum to provide the desired compound, used in the next step without further purification.

후처리

  1. concentrationThe reaction was concentrated to dryness under vacuum

출처 및 근거

ORD 기록
ord-b5896a84eebc46b49bf202c9bb13382c
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096593B2

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