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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2,6-Dimethylpiperazine → 5-chloro-N-[4-(3,5-dimethylpiperazin-1-yl)-2-methoxyphenyl]-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-amine

HRID 51
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인쇄 미리보기

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HRID 51 반응식
CC1CNCC(C)N1.COc1cc(Br)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1>C1COCCO1.CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>COc1cc(N2CC(C)NC(C)C2)ccc1Nc1ncc(Cl)c(-c2cnc3ccccn23)n1
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참가 물질

7

반응물 2

HCID 660562,6-DimethylpiperazineHCID 178418214HCID 178418214, 화합물

생성물 1

HCID 685928185-chloro-N-[4-(3,5-dimethylpiperazin-1-yl)-2-methoxyphenyl]-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-amine수율 0%

시약·촉매·용매 4

HCID 10796Cesium carbonate시약HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)촉매

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온도
140 °C

실험 절차

N-(4-bromo-2-methoxyphenyl)-5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine (107 mg, 0.25 mmol), 2,6-dimethylpiperazine (28.4 mg, 0.25 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (5.75 mg, 9.94 µmol), diacetoxypalladium (1.116 mg, 4.97 µmol) and cesium carbonate (162 mg, 0.50 mmol) were suspended in 1,4-dioxane (2 mL) . The reaction was purged with nitrogen and heated to 140 °C for 6 hours in an oil bath. Control LC/MS : no traces of expected product.

출처 및 근거

ORD 기록
ord-d5a89652aac64eea875d9bd85a60b6b2
출처 데이터셋
750 AstraZeneca ELN dataset
원본 링크
출처 보기

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이 페이지에서참가 물질반응 조건실험 절차출처 및 근거반응 노트
HCID 4144353
Palladium (II) acetate
촉매
HCID 312751,4-Dioxane용매