Ethanolamine → 2,4-difluoro-N-(2-hydroxyethyl)benzamide
반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].[F:5][C:6]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:7]=1[C:8](Cl)=[O:9]>C1COCC1.C(OCC)(=O)C>[F:5][C:6]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:7]=1[C:8]([NH:4][CH2:3][CH2:1][OH:2])=[O:9]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of ethanolamine (1.10 g, 15.8 mmol) in THF at 0° C. under N2 was added 2,4-difluorobenzoyl chloride (500 mg, 2.83 mmol). The reaction mixture was stirred at 0° C. for 4 h, then diluted with ethyl acetate (100 mL) and washed with 1 N HCl (50 mL), saturated NaHCO3 (50 mL), and saturated NaCl (50 mL). The organic solution was dried over MgSO4 and concentrated in vacuo to yield 2,4-difluoro-N-(2-hydroxyethyl)benzamide as a white solid (495 mg, 87%).
후처리
- washwashed with 1 N HCl (50 mL), saturated NaHCO3 (50 mL), and saturated NaCl (50 mL)
- dry with materialThe organic solution was dried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-084e64c90f2c4f3cbc32025195d73cff
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713471B1
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