Thionyl Chloride → 3,5-Difluoropyridine-2-carbonyl chloride

반응식

[F:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([C:9]([Cl:14])=[O:11])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 27832623,5-Difluoropyridine-2-carboxylic acid

생성물 1

HCID 866606483,5-Difluoropyridine-2-carbonyl chloride

실험 절차

A suspension of 5.00 g (31.4 mmol) of 3,5-difluoropyridine-2-carboxylic acid in thionyl chloride (21 ml) was heated to reflux for 5 h. The solution was concentrated, and the residue was twice taken up in a little toluene and concentrated again. This gave 3.80 g of a solid, which was converted further directly without further purification.

후처리

temperaturewas heated
temperatureto reflux for 5 h
concentrationThe solution was concentrated
concentrationconcentrated again
customThis gave 3.80 g of a solid, which was converted further directly without further purification

출처 및 근거

ORD 기록: ord-e286ced9dba54572b80536d8c8b65e27
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09096592B2

반응 노트

불러오는 중…