Water → 2-(2,3-dihydro-1H-inden-2-yl)ethanol
반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[CH2:10][C:11](OCC)=[O:12].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>CCOCC.CCOC(C)=O.[O-]S([O-])(=O)=O.[Mg+2]>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][CH:2]1[CH2:10][CH2:11][OH:12]참가 물질
7
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of ethyl 2,3-dihydo-1H-inden-2-ylacetate (285 mg, 1.39 mmol) in Et2O (5 mL) at 0° C. under N2 was added LAH (53 mg, 1.39 mmol). After stirring for 40 minutes at 0° C., 0.4 mL of H2O was added to quench the reaction. The reaction mixture was diluted with EtOAc (100 mL) and MgSO4 was added with stirring. The reaction mixture was then filtered and concentrated in vacuo to a clear oil. 2-(2,3-dihydro-1H-inden-2-yl)ethanol was isolated without further purification.
후처리
- customto quench
- customthe reaction
- additionwas added
- stirringwith stirring
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated in vacuo to a clear oil
출처 및 근거
- ORD 기록
- ord-13ceb885699d40588d203440eb85e2b0
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713471B1
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