Triethylsilane → HCID 66635174, 화합물

HRID 510144노트

반응식

HRID 510144 반응식
COC1C=C(OC)C=CC=1C[N:6]1[C:10]2[N:11]=[C:12]([C:15]3[C:23]4[C:18](=[N:19][CH:20]=[C:21]([F:24])[CH:22]=4)[N:17]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[F:32])[N:16]=3)[N:13]=[CH:14][C:9]=2[N:8]([CH3:33])[S:7]1(=[O:35])=[O:34].C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[F:24][C:21]1[CH:22]=[C:23]2[C:15]([C:12]3[N:13]=[CH:14][C:9]4[N:8]([CH3:33])[S:7](=[O:34])(=[O:35])[NH:6][C:10]=4[N:11]=3)=[N:16][N:17]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[C:18]2=[N:19][CH:20]=1

참가 물질

4

반응물 2

HCID 12052TriethylsilaneHCID 66634917HCID 66634917, 화합물

생성물 1

HCID 66635174HCID 66635174, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

28 mg (0.050 mmol) of the compound from example 100A were dissolved in 1.5 ml of trifluoroacetic acid and then admixed with 79 μl (0.495 mmol) of triethylsilane, and the mixture was heated to reflux overnight. This was followed by concentration to dryness. After purification by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient), this gave 10.4 mg (48% of theory) of the title compound.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. concentrationThis was followed by concentration to dryness
  4. customAfter purification by means of preparative HPLC (acetonitrile:water (+0.05% formic acid) gradient)

출처 및 근거

ORD 기록
ord-11dc3467c9e14bc6bb633252a589f161
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096592B2

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