Dimethylformamide → 2-Fluoro-3-(trifluoromethyl)benzoyl chloride

HRID 510232노트

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HRID 510232 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13]C=1C(O)=O.CN(C=O)C>C(Cl)Cl>[F:7][C:8]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:1]=1[C:2]([Cl:4])=[O:3]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 5180022-Fluoro-3-(trifluoromethyl)benzoic acid

생성물 1

HCID 27375592-Fluoro-3-(trifluoromethyl)benzoyl chloride수율 99.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Oxalyl chloride (0.488 mL, 5.76 mmol) was added to a suspension of 2-fluoro-3-(trifluoromethyl)benzoic acid (1.00 g, 4.81 mmol) in DCM (10 mL) containing catalytic DMF. The reaction was stirred at room temperature for 90 minutes and solvents were removed in vacuo to afford the desired compound (1.08 g, 99%). The product was used without additional purification.

후처리

  1. customsolvents were removed in vacuo

출처 및 근거

ORD 기록
ord-050408838199402b9bf1d1e4faa20359
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096596B2

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