Potassium Carbonate → (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate

온도

120 °C

The mixture of (S)-2-(2-(3-(benzyloxy)phenyl)-7-bromo-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (100 mg, 0.164 mmol), 4-chlorophenylboronic acid (38 mg, 0.246 mmol), 2N K2CO3 (400 μL), Pd(PPh3)4 (18 mg, 0.016 mmol) in dioxane in sealed tube was heated at 120° C. After the reaction is finished, the reaction mixture was washed by sat. NaHCO3, extracted by EtOAc, the organic phase was dried over MgSO4, filtered, concentrated down and purified by silica gel column (0-50% EtOAc in Hexanes) to give the product (103 mg, 97%). LCMS-ESI+: calc'd for C38H40ClNO4S: 642.2 (M+H+); Found: 642.3 (M+H+).

1. washthe reaction mixture was washed by sat. NaHCO3
2. extractionextracted by EtOAc
3. dry with materialthe organic phase was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated down
6. custompurified by silica gel column (0-50% EtOAc in Hexanes)

ORD 기록

ord-1b7adee157b74e8091ce663ff8444acf

출처 데이터셋

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09096586B2