2-Fluoro-4-(trifluoromethyl)benzaldehyde → 2-Methoxy-4-(trifluoromethyl)benzaldehyde

HRID 510586노트

반응식

HRID 510586 반응식
F[C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:14][O-:15].[Na+]>>[CH3:14][O:15][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

3

반응물 2

HCID 5229292-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 10942334Sodium Methoxide

생성물 1

HCID 49847042-Methoxy-4-(trifluoromethyl)benzaldehyde수율 85%

반응 조건

온도
50 °C

실험 절차

2-Fluoro-4-(trifluoromethyl)benzaldehyde (5.0 g, 26 mmol) was diluted with sodium methoxide (57 ml of 0.5 M in methanol; 29 mmol), heated to 50° C. and stirred for 6 hours. The reaction was then partially concentrated, diluted with ethyl acetate and water. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield 2-methoxy-4-(trifluoromethyl)benzaldehyde (4.5 g, 22 mmol, 85% yield).

후처리

  1. concentrationThe reaction was then partially concentrated
  2. additiondiluted with ethyl acetate and water
  3. customThe layers were separated
  4. dry with materialthe organic layer was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6e93e24f57ed4f2eaee1874c26441e06
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096567B2

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