Nitromethane → 4-Chloro-2-methyl-1-(2-nitrovinyl)benzene

HRID 510632노트

반응식

HRID 510632 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([CH3:10])[CH:3]=1.Cl.CN.C([O-])(=O)C.[Na+].[N+:19]([CH3:22])([O-:21])=[O:20]>O.ClCCl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:22][N+:19]([O-:21])=[O:20])=[C:4]([CH3:10])[CH:3]=1

참가 물질

7

반응물 4

HCID 6375NitromethaneHCID 517045Sodium AcetateHCID 27576584-Chloro-2-methylbenzaldehydeHCID 6364545Methylamine hydrochloride

생성물 1

HCID 670259694-Chloro-2-methyl-1-(2-nitrovinyl)benzene수율 94%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

A mixture of 4-chloro-2-methylbenzaldehyde (1.56 g, 10.1 mmol), methylamine hydrochloride (0.44 g, 6.5 mmol), and sodium acetate (0.53 g, 6.5 mmol) in nitromethane (4 mL) was vigorously stirred at ambient temperature for 24 hours. The reaction mixture was diluted with water (20 mL) and dichloromethane (40 mL). The organic layer was dried over sodium sulfate and evaporated to afford 4-chloro-2-methyl-1-(2-nitrovinyl)benzene as a light brown solid (1.87 g, 94% yield).

후처리

  1. dry with materialThe organic layer was dried over sodium sulfate
  2. customevaporated

출처 및 근거

ORD 기록
ord-ab36ae914539488985cc6db4e457eaf8
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096567B2

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