[NH:1]([CH:5]=O)[NH:2][CH:3]=O.Cl[Si](C)(C)C.C(N(CC)CC)C.[NH2:19][C:20]1[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=2)=[C:24]([C:33](=[O:35])[CH3:34])[CH:23]=[C:22]([Cl:36])[C:21]=1[CH3:37]>N1C=CC=CC=1.O>[Cl:36][C:22]1[C:21]([CH3:37])=[C:20]([N:19]2[CH:3]=[N:2][N:1]=[CH:5]2)[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=2)=[C:24]([C:33](=[O:35])[CH3:34])[CH:23]=1
1,2-Hydrazinedicarboxaldehyde (0.095 g, 1.1 mmol) and then, drop by drop, chlorotrimethylsilane (0.69 mL, 5.4 mmol) and triethylamine (0.35 mL, 2.5 mmol) were added to a suspension of 1-(6-amino-4-chloro-3′-fluoro-5-methylbiphenyl-2-yl)ethanone (0.10 g, 0.36 mmol) in pyridine (2 mL). The mixture was heated at 100° C. overnight. Evaporation at reduced pressure of the solvent yielded a solid that was treated with water and extracted with dichloromethane. The extracts were dried over sodium sulfate and concentrated. The reside was purified on silica gel, eluting with 0 to 50% ethyl acetate in hexane, then 0 to 10% methanol in dichloromethane, to give the desired product (44 mg, 37%). LCMS calculated for C17H14ClFN3O (M+H)+: m/z=330.1. found: 330.0.
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