Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Benzyloxyaniline → (4-Benzyloxyphenyl)-(6-iodoquinazolin-4-yl)-amine Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Benzyloxyaniline | HCID 22860 | — |
| 반응물 | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (4-Benzyloxyphenyl)-(6-iodoquinazolin-4-yl)-amine Hydrochloride | HCID 21951949 | 97.4% |
반응 단계
4-Chloro-6-iodoquinazoline (8 g) was treated with 4-benzyloxyaniline (5.5 g) in acetonitrile (500 ml) at reflux under N2 for 18 hours. Subsequent cooling and filtration gave the title compound (13.13 g); δH [2H6]-DMSO 11.45 (1H, b, NH), 9.22 (1H, s, 5-H), 8.89 (1H, s, 2-H), 8.36 (1H, d, 7-H), 7.69 (1H, d, 8-H), 7.63 (2H, d, 2′-H, 6′-H), 7.52-7.29 (5H, m, Ph-H), 7.14 (2H, d, 3′-H, 5′-H), 5.18 (2H, s, CH2); m/z (M+1)+454.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713485B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-e6586aebed944cca8f55f69f28176000 |
| 출처 메모 | uspto-grants-2004_03 |