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Potassium Iodide → 4-[4-(4-Tert-butyl-phenyl)-piperazin-1-yl]-butyric acid ethyl ester

HRID 511202
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HRID 511202 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:17]([O:19][C:20](=[O:25])[CH2:21][CH2:22][CH2:23]Br)[CH3:18].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[CH2:17]([O:19][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][N:14]1[CH2:15][CH2:16][N:11]([C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=2)[CH2:12][CH2:13]1)[CH3:18]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrateHCID 7817221-(4-tert-Butylphenyl)piperazine

생성물 1

HCID 585764584-[4-(4-Tert-butyl-phenyl)-piperazin-1-yl]-butyric acid ethyl ester수율 84.8%

시약·촉매·용매 1

HCID 6342
Acetonitrile
용매

실험 절차

A mixture of 1-(4-tert-butyl-phenyl)-piperazine (1.09 mg; 5.0 mmol), 4-bromo-butyric acid ethyl ester (975 mg; 5.0 mmol), potassium carbonate (691 mg; 5.0 mmol) and potassium iodide (914 mg; 5.5 mmol) in acetonitrile (15 mL) is heated to reflux for 2 hours. The reaction mixture is allowed to attain room temperature and all solids removed by filtration. The filtration residue is washed with acetonitrile and the filtrate concentrated under high vacuum to afford the desired compound (1.41 g; 4.24 mmol).

후처리

  1. temperatureis heated
  2. temperatureto reflux for 2 hours
  3. customto attain room temperature
  4. customall solids removed by filtration
  5. washThe filtration residue is washed with acetonitrile
  6. concentrationthe filtrate concentrated under high vacuum

출처 및 근거

ORD 기록
ord-6e19fe14b5e54f6290f575841c691bff
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09096524B2

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