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Trifluoroacetic acid → Dibutyl[4-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate trifluoroacetate

HRID 511253
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인쇄 미리보기

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HRID 511253 반응식
[NH2:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][P:7](=[O:18])([O:13][CH2:14][CH2:15][CH2:16][CH3:17])[O:8][CH2:9][CH2:10][CH2:11][CH3:12])=[CH:4][CH:3]=1.Cl[C:22]1[N:27]=[C:26]([NH:28][CH2:29][C:30]2[C:31]([N:36]([CH3:41])[S:37]([CH3:40])(=[O:39])=[O:38])=[N:32][CH:33]=[CH:34][CH:35]=2)[C:25]([C:42]([F:45])([F:44])[F:43])=[CH:24][N:23]=1.[C:46]([OH:52])([C:48]([F:51])([F:50])[F:49])=[O:47]>>[F:49][C:48]([F:51])([F:50])[C:46]([OH:52])=[O:47].[CH3:41][N:36]([S:37]([CH3:40])(=[O:39])=[O:38])[C:31]1[C:30]([CH2:29][NH:28][C:26]2[C:25]([C:42]([F:45])([F:43])[F:44])=[CH:24][N:23]=[C:22]([NH:1][C:2]3[CH:3]=[CH:4][C:5]([CH2:6][P:7](=[O:18])([O:8][CH2:9][CH2:10][CH2:11][CH3:12])[O:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:19][CH:20]=3)[N:27]=2)=[CH:35][CH:34]=[CH:33][N:32]=1
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참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 22221324Dibutyl(4-aminobenzyl)phosphonateHCID 57584561N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide

생성물 1

HCID 86654004Dibutyl[4-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate trifluoroacetate수율 73%

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온도
105 °C

실험 절차

A mixture of dibutyl (4-aminobenzyl)phosphonate (18 mg, 0.06 mmol), N-[3-({[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}methyl)pyridin-2-yl]-N-methylmethanesulfonamide XLIa (20 mg, 0.05 mmol), TFA (12 uL, 0.15 mmol) and TFE (0.5 mL) was heated at 105° C. under nitrogen in a microwave reactor for 40 minutes. The resulting mixture was concentrated in vacuo and the residue purified by preparative HPLC (MDP) to afford 24 mg of dibutyl [4-({4-[({2-[methyl(methylsulfonyl)amino]pyridin-3-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate trifluoroacetate (Example 26, yield 73%).

후처리

  1. concentrationThe resulting mixture was concentrated in vacuo
  2. customthe residue purified by preparative HPLC (MDP)

출처 및 근거

ORD 기록
ord-c46239c0d1334e2c836326b64d3442a5
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09096624B2

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