4-Fluoro-2-nitrobenzoic acid → 4-fluoro-N-methyl-2-nitrobenzamide

반응식

F[C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([NH:9][CH3:10])=[O:8].[F:15]C1C=CC(C(O)=O)=C([N+]([O-])=O)C=1>>[F:15][C:3]1[CH:2]=[CH:11][C:6]([C:7]([NH:9][CH3:10])=[O:8])=[C:5]([N+:12]([O-:14])=[O:13])[CH:4]=1

참가 물질

반응물 2

HCID 27374164-Fluoro-2-nitrobenzoic acid

HCID 442030775-Fluoro-N-methyl-2-nitrobenzamide2회

생성물 1

HCID 671150044-fluoro-N-methyl-2-nitrobenzamide

실험 절차

The title compound was prepared using the procedure from 5-fluoro-N-methyl-2-nitrobenzamide (Compound 102B) with the commercially available 4-fluoro-2-nitrobenzoic acid. 1H NMR (CDCl3, 400 MHz): δ=3.04 (d, J=4.80 Hz, 3 H), 5.88 (br. s., 1 H), 7.39 (ddd, J=8.46, 7.45, 2.53 Hz, 1 H), 7.55 (dd, J=8.59, 5.31 Hz, 1 H), 7.78 (dd, J=8.34, 2.53 Hz, 1 H). MS (ES+): m/z 199.05 [MH+] (TOF, polar).

출처 및 근거

ORD 기록: ord-37675c302e5f45518cfaed89cec6f5b1
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09096624B2

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