Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Phenylmethyl)-1H-indazol-5-amine → (1-Benzylindazol-5-yl)-(6-iodoquinazolin-4-yl)-amine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Phenylmethyl)-1H-indazol-5-amine | HCID 212069 | — |
| 반응물 | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (1-Benzylindazol-5-yl)-(6-iodoquinazolin-4-yl)-amine hydrochloride | HCID 21952130 | 92% |
반응 단계
Prepared according to Procedure A from 4-chloro-6-iodoquinazoline (5.8 g) was treated with 5-amino-1-benzyl-1H-indazole (3.90 g) in acetonitrile (500 ml) at reflux under N2 for 18 hours. Subsequent cooling and filtration gave the title compound (8.26 g); m/z (M+1)+478.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713485B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-9d90ed422acc4763921bfa34724190ec |
| 출처 메모 | uspto-grants-2004_03 |