Trifluoroacetic acid → 7-amino-2-methyl-4-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-1-one

HRID 511311노트

반응식

HRID 511311 반응식
[CH3:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[C:5]([C:20]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:21])[CH:6]=[CH:7][C:8]=2[NH:12]C(=O)OC(C)(C)C)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:12][C:8]1[CH:7]=[CH:6][C:5]([C:20]([N:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)=[O:21])=[C:4]2[C:9]=1[C:10](=[O:11])[N:2]([CH3:1])[CH2:3]2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86654017tert-butyl[2-methyl-3-oxo-7-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-4-yl]carbamate2회

생성물 1

HCID 672554307-amino-2-methyl-4-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-1-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To tert-butyl [2-methyl-3-oxo-7-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-4-yl]carbamate (Compound 116B) was added DCM (0.5 mL) and TFA (0.5 mL). The reaction mixture was stirred at room temperature for 30 minutes, after which it was concentrated to dryness an used without further purification. MS (ES+): m/z 260.30 (100) [MH+]; HPLC: tR=0.69 min (UPLC, Analytical).

후처리

  1. concentrationafter which it was concentrated to dryness
  2. customan used without further purification

출처 및 근거

ORD 기록
ord-eac491fedda84dbc88a32c530f8828b7
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096624B2

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