3-Fluoro-5-methoxy-4-nitrobenzoic acid → (3-Fluoro-5-methoxy-4-nitrophenyl)methanol

반응식

FC1C=C([N+]([O-])=O)C(OC)=CC=1C(O)=O.[F:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([O:29][CH3:30])[C:25]=1[N+:26]([O-:28])=[O:27])[C:20](O)=[O:21]>>[F:16][C:17]1[CH:18]=[C:19]([CH2:20][OH:21])[CH:23]=[C:24]([O:29][CH3:30])[C:25]=1[N+:26]([O-:28])=[O:27]

참가 물질

반응물 2

HCID 579555223-Fluoro-5-methoxy-4-nitrobenzoic acid2회

HCID 579556142-Fluoro-5-methoxy-4-nitrobenzoic acid

생성물 1

HCID 67256643(3-Fluoro-5-methoxy-4-nitrophenyl)methanol

실험 절차

The title compound was prepared using the procedure from Compound 130E (2-fluoro-5-methoxy-4-nitrobenzoic acid) with 3-fluoro-5-methoxy-4-nitrobenzoic acid (Compound 146E). 1H NMR (CDCl3, 400 MHz): δ=3.95 (s, 3 H), 4.76 (s, 2 H), 6.81-6.86 (m, 1 H), 6.88 (s, 1 H). MS (ES+): m/z 202.05 [MH+] (TOF, polar).

출처 및 근거

ORD 기록: ord-4125d20dfa934cf68978de0c6db482df
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09096624B2

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