2-Fluoro-3-methoxy-4-nitrobenzoic acid → (2-Fluoro-3-methoxy-4-nitrophenyl)methanol

반응식

FC1C=C([N+]([O-])=O)C(OC)=CC=1CO.[F:15][C:16]1[C:24]([O:25][CH3:26])=[C:23]([N+:27]([O-:29])=[O:28])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19]>>[F:15][C:16]1[C:24]([O:25][CH3:26])=[C:23]([N+:27]([O-:29])=[O:28])[CH:22]=[CH:21][C:17]=1[CH2:18][OH:19]

참가 물질

반응물 2

HCID 579556232-Fluoro-3-methoxy-4-nitrobenzoic acid2회

HCID 67255286(2-Fluoro-5-methoxy-4-nitrophenyl)methanol

생성물 1

HCID 67254223(2-Fluoro-3-methoxy-4-nitrophenyl)methanol

실험 절차

The title compound was prepared using the procedure from Compound 130D ((2-fluoro-5-methoxy-4-nitrophenyl)methanol) with 2-fluoro-3-methoxy-4-nitrobenzoic acid (Compound 147E). 1H NMR (CDCl3, 400 MHz): δ=4.08 (d, J=1.77 Hz, 3 H), 4.85 (s, 2 H), 7.29-7.35 (m, 1 H), 7.64 (dd, J=8.46, 1.89 Hz, 1 H).

출처 및 근거

ORD 기록: ord-edea00627a624e24a8a9bc4b74a5b216
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09096624B2

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