2-Fluoro-6-nitrobenzoic acid → 2-fluoro-N-methyl-6-nitrobenzamide

반응식

F[C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([NH:9][CH3:10])=[O:8].[F:15]C1C=CC=C([N+]([O-])=O)C=1C(O)=O>>[F:15][C:11]1[CH:2]=[CH:3][CH:4]=[C:5]([N+:12]([O-:14])=[O:13])[C:6]=1[C:7]([NH:9][CH3:10])=[O:8]

참가 물질

반응물 2

HCID 6037582-Fluoro-6-nitrobenzoic acid

HCID 442030775-Fluoro-N-methyl-2-nitrobenzamide

생성물 1

HCID 672557082-fluoro-N-methyl-6-nitrobenzamide

실험 절차

The title compound was prepared according to the procedure for Compound 102B (5-fluoro-N-methyl-2-nitrobenzamide) using 2-fluoro-6-nitrobenzoic acid. 1H NMR (CDCl3, 400 MHz): δ=3.09 (d, J=5.05 Hz, 3 H), 7.45 (td, J=8.34, 1.01 Hz, 1 H), 7.56 (td, J=8.27, 5.43 Hz, 1 H), 7.94 (dt, J=8.08, 1.01 Hz, 1 H). MS (ES+): m/z 199.05 [MH+] (TOF, polar).

출처 및 근거

ORD 기록: ord-fbf04446a305463a91a677b3fc941ae5
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09096624B2

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