Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Methylsulfonyl)ethanamine → Deschloro Lapatinib
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Methylsulfonyl)ethanamine | HCID 4340561 | — |
| 반응물 | Lapatinib Impurity 22 | HCID 21952281 | — |
| 생성물 | Deschloro Lapatinib | HCID 9893671 | — |
반응 단계
Prepared according to Procedure D from 5-(4-{4-(3-fluorobenzyloxy)anilino}-6-quinazolinyl)-furan-2-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR 400 MHz (DMSO-d6) 9.40 (s, 1H); 8.67 (s, 1H); 8.30 (d, 1H); 7.86 (d, 1H); 7.75 (d, 2H); 7.43 (m, 1H); 7.30-7.21 (m, 3H); 7.15 (m, 1H); 7.07 (d, 2H); 6.80 (d, 1H); 5.15 (s, 2H); 4.40 (s, 2H); 3.65 (m, 2H); 3.40 (m, 2H); 3.11 (s, 3H); MS m/z 547 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713485B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-25910316860040f9924bfd1a30fb5ea0 |
| 출처 메모 | uspto-grants-2004_03 |