Nicotinamide → Declopramide hydrochloride

반응식

CCN(CCNC(C1C=CC(N)=CC=1)=O)CC.CCN(CCNC(C1C=CC(N)=C([Cl:35])C=1)=O)CC.[CH3:36][CH2:37][N:38]([CH2:41][CH2:42][NH:43][C:44]([C:46]1[CH:47]=[C:48]([Cl:55])[C:49]([NH2:54])=[CH:50][C:51]=1OC)=[O:45])[CH2:39][CH3:40].C(N)(=O)C1C=CC=NC=1.C(N(CC)CCC1N=CC=CC=1C(N)=O)C>>[ClH:35].[CH2:39]([N:38]([CH2:37][CH3:36])[CH2:41][CH2:42][NH:43][C:44](=[O:45])[C:46]1[CH:51]=[CH:50][C:49]([NH2:54])=[C:48]([Cl:55])[CH:47]=1)[CH3:40]

참가 물질

반응물 5

HCID 936Nicotinamide

HCID 4168Metoclopramide

HCID 4913Procainamide

HCID 70177Declopramide

HCID 867594092-Diethylamino-ethyl nicotinamide

생성물 1

HCID 22737404Declopramide hydrochloride

실험 절차

Reaction of aryl carboxamides with radiation. Aqueous 100 μM solutions of procainamide (4-amino-N-(2-diethylamino-ethyl)benzamide), 3-chloro-procainamide (N-(2-diethylamino-ethyl)-4-amino-3-chlorobenzamide), metoclopramide (4-amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxybenzamide), nicotinamide and N-(2-diethylamino-ethyl nicotinamide were given 1000 Gy of irradiation from 137cesium source (1.3 Gy/min., Scanditronix) at room temperature for 30 min. The various reaction mixtures were then vacuum evaporated to dryness, redissolved in methanol, spotted on silica gel 60 F245 thin layer chromatography (TLC) plates in 1-butanol:acetic acid:water (4:1:1, v/v/v), and visualized with short and long wave ultraviolet light and also in an iodine chamber, and the Rf values calculated in the conventional manner.