9-((3aR,4R,6R,6aR)-6-(((3-(azidomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine → 9-((3aR,4R,6R,6aR)-6-(((3-(aminomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

HRID 511585노트

반응식

HRID 511585 반응식
[N:1]([CH2:4][CH:5]1[CH2:8][CH:7]([N:9]([CH2:11][C@@H:12]2[C@H:16]3[O:17][C:18]([CH3:21])([CH3:20])[O:19][C@H:15]3[C@H:14]([N:22]3[CH:30]=[N:29][C:28]4[C:23]3=[N:24][CH:25]=[N:26][C:27]=4[NH2:31])[O:13]2)[CH3:10])[CH2:6]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH:5]1[CH2:6][CH:7]([N:9]([CH2:11][C@@H:12]2[C@H:16]3[O:17][C:18]([CH3:21])([CH3:20])[O:19][C@H:15]3[C@H:14]([N:22]3[CH:30]=[N:29][C:28]4[C:23]3=[N:24][CH:25]=[N:26][C:27]=4[NH2:31])[O:13]2)[CH3:10])[CH2:8]1

참가 물질

4

반응물 1

HCID 866661089-((3aR,4R,6R,6aR)-6-(((3-(azidomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

생성물 1

HCID 677761929-((3aR,4R,6R,6aR)-6-(((3-(aminomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Pd/C (10 mg) was added to a solution of 9-((3aR,4R,6R,6aR)-6-(((3-(azidomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine (90 mg, 0.21 mmol) in MeOH (6 ml). The mixture was stirred at RT overnight under an atmosphere of H2. The mixture was filtered and the filtrate was concentrated to obtain the title compound which was used directly in the next step.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-bc585bb9fa104fa08843d18a5354cc88
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096634B2

반응 노트

불러오는 중…