2-Thiophenecarboxaldehyde → HCID 178524223, 화합물

HRID 51167

반응식

HRID 51167 반응식
[C:1]([NH:18][C@H:19]([C:26]([OH:28])=[O:27])[CH2:20][C:21]1[N:25]=[CH:24][NH:23][CH:22]=1)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(N[C@H:47]([C:52]([OH:54])=[O:53])[CH2:48]C(C)C)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.S1C=[CH:58][CH:57]=[C:56]1[CH:60]=[O:61].Cl[C:63]1[CH:64]=[C:65]([CH:69]=[CH:70][C:71]=1[Cl:72])[C:66](Cl)=[O:67]>>[Cl:72][C:71]1[CH:70]=[CH:69][C:65]([C:66]([N:18]2[CH:1]([C:60]3[O:61][CH:58]=[CH:57][CH:56]=3)[CH:47]([C:52]([OH:54])=[O:53])[CH2:48][C:19]2([CH2:20][C:21]2[N:25]=[CH:24][NH:23][CH:22]=2)[C:26]([OH:28])=[O:27])=[O:67])=[CH:64][CH:63]=1

참가 물질

5

반응물 4

HCID 73642-ThiophenecarboxaldehydeHCID 76403Benzoyl chloride, 3,4-dichloro-HCID 1549133Fmoc-leucineHCID 178523876HCID 178523876, 화합물

생성물 1

HCID 178524223HCID 178524223, 화합물

실험 절차

Following the procedure of Example 28(a)-28(d), except beginning with Wang bound Fmoc-L-histidine (Trt) instead of Wang bound Fmoc-L-leucine, and substituting furan-2-carboxaldehyde for thiophene-2-carboxaldehyde, and substituting 4-chlorobenzoylchloride for 3,4-dichlorobenzoyl chloride, the title compound was prepared as a solid. MS [M+H]+444.8

출처 및 근거

ORD 기록
ord-3adcf0f3a9694e53b5a862322e9894d9
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713502B2

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