홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Monobenzone → 1-(Benzyloxy)-4-(4,4,4-trifluorobutoxy)benzene

HRID 511717
노트
인쇄 미리보기

반응식

HRID 511717 반응식
I[CH2:2][CH2:3][CH2:4][C:5]([F:8])([F:7])[F:6].[CH2:9]([O:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1>[CH2:9]([O:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH2:2][CH2:3][CH2:4][C:5]([F:8])([F:7])[F:6])=[CH:21][CH:22]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 7638MonobenzoneHCID 11430Potassium CarbonateHCID 27751891,1,1-Trifluoro-4-iodobutane

생성물 1

HCID 674558991-(Benzyloxy)-4-(4,4,4-trifluorobutoxy)benzene

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
80 °C

실험 절차

464.5 g (1.95 mol) of 4-iodo-1,1,1-trifluorobutane, 390.4 g (1.95 mol) of 4-(benzyloxy)phenol and 539.5 g (3.90 mol) of potassium carbonate are dissolved in 3 L of NMP. The mixture is heated to 80° C. overnight. The solution is cooled to room temperature and the reaction mixture is extracted with ethyl acetate and water. The organic phase is washed repeatedly with water, dried over sodium sulfate, filtrated and concentrated under reduced pressure to give 580 g of

후처리

  1. temperatureThe solution is cooled to room temperature
  2. extractionthe reaction mixture is extracted with ethyl acetate and water
  3. washThe organic phase is washed repeatedly with water
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltrated
  6. concentrationconcentrated under reduced pressure
  7. customto give 580 g of

출처 및 근거

ORD 기록
ord-cb97ab61a24c45898f59e4681835123c
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09097938B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트