Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 4-(Heptafluoropropylthio)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Aminothiophenol | HCID 14510 | — |
| 반응물 | Perfluoropropyl iodide | HCID 33977 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-(Heptafluoropropylthio)aniline | HCID 2052609 | 63.2% |
반응 단계
To an acetonitrile solution (20 ml) of 4-aminothiophenol (1.25 g, 9.98 mmol) and triethylamine (1.11 g, 11.0 mmol) was added 1-iodoheptafluoro-n-propane (5.91 g, 19.9 mmol), and the resultant mixture was stirred at room temperature for 3 hours. The mixture was diluted with ether, and washed with a 1N sodium hydroxide aqueous solution. Then, the product was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=4:1) to obtain 1.85 g (yield 63%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09101135B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-832718530f554600bd472156ffa9057a |
| 출처 메모 | uspto-grants-2015_08 |