참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl Acrylate | HCID 7294 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Bromo-3-nitrotoluene | HCID 231828 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 3-(2-methyl-6-nitrophenyl)propenoate | HCID 67291648 | 48% |
반응 단계
2-Bromo-3-nitrotoluene (0.5 g, 23 mmol), methyl acrylate (0.39 g, 46 mmol,), palladium acetate (29 mg, 1.3 mmol), triphenylphosphine (0.06 g, 0.23 mmol,) and TEA (0.4 mL) were combined in a sealed tube and heated to 95° C. for 24 h. The residue was dissolved in MeOH, the solvent was removed and the crude product was purified by column chromatography (EtOAc:hexane=7.5:92.5) to give 0.024 g (48% yield) of the title compound as a yellow oil:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09101616B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-ea82058354304b6eb4d6d3506ca40fde |
|---|
| 출처 메모 | uspto-grants-2015_08 |
|---|
