(R)-4-Phenylpyrrolidin-2-one → 1-Pyrrolidineacetamide, 2-oxo-4-phenyl-, (4S)-

HRID 511927노트

반응식

HRID 511927 반응식
[C:1]1([C@@H:7]2[CH2:11][NH:10][C:9](=[O:12])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([C@H]2C[NH:22][C:21](=[O:24])[CH2:20]2)C=CC=CC=1>CO>[C:21]([CH2:20][N:10]1[CH2:11][C@H:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][C:9]1=[O:12])(=[O:24])[NH2:22]

참가 물질

4

반응물 2

HCID 641621(R)-4-Phenylpyrrolidin-2-oneHCID 757631HCID 757631, 화합물

생성물 1

HCID 7818841-Pyrrolidineacetamide, 2-oxo-4-phenyl-, (4S)-

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Substituting pyrrolidinone 1 in Example 1 by 4(S)-phenyl-2-pyrrolidinone (1a) S-enantiomeric N-carbamoylmethyl-4(S)-phenyl-2-pyrrolidinone (4a) was obtained. [α]D20=−8.3° (c=3, MeOH). 1H NMR (CDCl3), δ: 2.61 (1H, d, d, 3-CH2); 2.87 (1H, d, d, 3-CH2); 3.54 (1H, t, 5-CH2); 3.66 (1H, quintet, 4-CH); 3.89 (1H, t, 5-CH2); 4.00 (2H, s, NCH2CO); 5.68 and 6.21 (1H and 1H, br.s and br.s, NH2); 7.20-7.40 (5H, m, C6H5).

후처리

  1. customwas obtained

출처 및 근거

ORD 기록
ord-96a70ad3e21744669a4d88d3a1c85935
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102615B2

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