Sodium Azide → 4-Bromobenzyl azide
반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:10]=[N+:11]=[N-:12])=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of 4-bromobenzyl bromide (54) and sodium azide (2.0 equiv.) in DMF was stirred at 50° C. for 3 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The combined organic extract was dried over MgSO4 and concentrated in vacuo. The residue was purified by flash chromatography to yield 55 as colorless oil in 92% yield.
후처리
- extractionextracted with CH2Cl2
- extractionThe combined organic extract
- dry with materialwas dried over MgSO4
- concentrationconcentrated in vacuo
- customThe residue was purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-be285720f74844ac9e2e1175a5d03926
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102622B2
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