Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloride → 2-(5-Chloropyridin-3-yl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| 생성물 | 2-(5-Chloropyridin-3-yl)acetonitrile | HCID 55265902 | — |
반응 단계
Conversion of the hydroxyl group to the chloride using thionyl chloride, followed by the displacement of the chloride by potassium cyanide was performed using the same procedures described for (6-trifluoromethyl-pyridin-3-yl)-acetonitrile. 1H NMR (400 MHz, CDCl3) δ ppm 8.55 (d, J=2.0 Hz, 1 H), 8.50 (d, J=1.1 Hz, 1 H), 7.73 (s, 1 H), 4.58 (s, 2 H). MS m/z 153.0
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102591B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-7629e815c06247809eb898374acc3379 |
| 출처 메모 | uspto-grants-2015_08 |