Methanesulfonic Acid → 5-(Diisopropoxymethyl)-2-methylpyrimidine

HRID 512199

반응식

HRID 512199 반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5](C=O)=[CH:4][N:3]=1.C(O[CH:14]([O:19][CH:20]([CH3:22])[CH3:21])[O:15][CH:16]([CH3:18])[CH3:17])(C)C.CS(O)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C>[CH:20]([O:19][CH:14]([O:15][CH:16]([CH3:17])[CH3:18])[C:5]1[CH:4]=[N:3][C:2]([CH3:1])=[N:7][CH:6]=1)([CH3:21])[CH3:22]

참가 물질

6

반응물 4

HCID 6395Methanesulfonic AcidHCID 11430Potassium CarbonateHCID 78191Propane, 2,2',2''-[methylidynetris(oxy)]tris-HCID 31609702-Methylpyrimidine-5-carbaldehyde

생성물 1

HCID 867162275-(Diisopropoxymethyl)-2-methylpyrimidine수율 29.1%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a mixture of 2-methylpyrimidine-5-carbaldehyde (1.0 g, 8.2 mmol) and triisopropoxymethane (2.3 g, 12 mmol) in isopropanol (15 ml) was added methanesulfonic acid (0.079 g, 0.053 ml, 0.819 mmol). The reaction was stirred at room temperature for 23 hours. Potassium carbonate (1.132 g, 8.19 mmol) was added and the mixture was filtered and the solution was concentrated in vacuo. The crude mixture was purified by flash chromatography to yield 5-(diisopropoxymethyl)-2-methylpyrimidine (536 mg, 29%)

후처리

  1. filtrationthe mixture was filtered
  2. concentrationthe solution was concentrated in vacuo
  3. customThe crude mixture was purified by flash chromatography

출처 및 근거

ORD 기록
ord-4fe02f5b96f2459190c5311e99599d9b
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102591B2

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