2-Chloro-5-(trifluoromethyl)benzoic acid → 2-Chloro-N-[[4,4-difluoro-1-(6-fluoro-3-pyridyl)cyclohexyl]methyl]-5-(trifluoromethyl)benzamide

HRID 512229노트

반응식

HRID 512229 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:15][C:16]1([F:31])[CH2:21][CH2:20][C:19]([CH2:29][NH2:30])([C:22]2[CH:23]=[N:24][C:25]([F:28])=[CH:26][CH:27]=2)[CH2:18][CH2:17]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([NH:30][CH2:29][C:19]1([C:22]2[CH:23]=[N:24][C:25]([F:28])=[CH:26][CH:27]=2)[CH2:20][CH2:21][C:16]([F:15])([F:31])[CH2:17][CH2:18]1)=[O:6]

참가 물질

3

반응물 2

HCID 6881822-Chloro-5-(trifluoromethyl)benzoic acidHCID 86716261[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine

생성물 1

HCID 867162642-Chloro-N-[[4,4-difluoro-1-(6-fluoro-3-pyridyl)cyclohexyl]methyl]-5-(trifluoromethyl)benzamide

실험 절차

From 2-chloro-5-trifluoromethylbenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=451.1, tR (minutes, Method C)=1.15

출처 및 근거

ORD 기록
ord-25e494ed761c4756b2ff1653407bedc4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102591B2

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