4-Cyano-2-fluorobenzoic acid → 4-Cyano-N-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-benzamide
반응식
[F:1][C:2]1[CH:10]=[C:9]([C:11]#[N:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:13][C:14]1([F:29])[CH2:19][CH2:18][C:17]([CH2:27][NH2:28])([C:20]2[CH:21]=[N:22][C:23]([F:26])=[CH:24][CH:25]=2)[CH2:16][CH2:15]1>>[C:11]([C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH:28][CH2:27][C:17]2([C:20]3[CH:21]=[N:22][C:23]([F:26])=[CH:24][CH:25]=3)[CH2:18][CH2:19][C:14]([F:13])([F:29])[CH2:15][CH2:16]2)=[O:6])=[C:2]([F:1])[CH:10]=1)#[N:12]참가 물질
3
실험 절차
From 2-fluoro-4-cyanobenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=392.1, tR (minutes, Method D)=0.68
출처 및 근거
- ORD 기록
- ord-27f861b7b00f4c42b560ba838bec922a
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102591B2
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