2-Fluoro-3-methoxybenzoic acid → N-[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-3-methoxybenzamide

HRID 512231노트

반응식

HRID 512231 반응식
[F:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:13][C:14]1([F:29])[CH2:19][CH2:18][C:17]([CH2:27][NH2:28])([C:20]2[CH:21]=[N:22][C:23]([F:26])=[CH:24][CH:25]=2)[CH2:16][CH2:15]1>>[F:29][C:14]1([F:13])[CH2:15][CH2:16][C:17]([CH2:27][NH:28][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH3:12])[C:2]=2[F:1])([C:20]2[CH:21]=[N:22][C:23]([F:26])=[CH:24][CH:25]=2)[CH2:18][CH2:19]1

참가 물질

3

반응물 2

HCID 33906792-Fluoro-3-methoxybenzoic acidHCID 86716261[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine

생성물 1

HCID 86716266N-[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-3-methoxybenzamide

실험 절차

From 2-fluoro-3-methoxybenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=397.2, tR (minutes, Method D)=0.69

출처 및 근거

ORD 기록
ord-f48ee2a9c0e14f37aae3e4390d6a513a
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102591B2

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