2-Chloro-6-fluorobenzoic acid → 2-chloro-6-fluoro-N-((4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methyl)benzamide

HRID 512287노트

반응식

HRID 512287 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[N:18]=[CH:17][C:16]([C:19]2([CH2:25][NH2:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:15][N:14]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:26][CH2:25][C:19]1([C:16]2[CH:17]=[N:18][C:13]([CH3:12])=[N:14][CH:15]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=[O:6]

참가 물질

3

반응물 2

HCID 679472-Chloro-6-fluorobenzoic acidHCID 86716331(4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methanamine

생성물 1

HCID 867163332-chloro-6-fluoro-N-((4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methyl)benzamide

실험 절차

From 2-chloro-6-fluorobenzoic acid and (4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methanamine. LCMS (MH+): m/z=364.1, tR (minutes, Method F)=1.57

출처 및 근거

ORD 기록
ord-7a00c9d67eea4d17ba5743e5b46da4bf
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102591B2

반응 노트

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