Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Ethyl-1H-pyrrole-3-carboxylic acid | HCID 22737923 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate | HCID 12146426 | — |
반응 단계
Into a suspension of 3.33 g (23.9 mmol) of 1-ethyl-3-pyrrolecarboxylic acid, 4.41 g (28.7 mmol) of β-alanine ethyl ester hydrochloride and 5.50 g (28.7 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride in 40 ml of methylene chloride, 4.0 ml (28.7 mmol) of triethylamine were added dropwise under ice cooling and stirring. The reaction mixture was stirred at room temperature for 2.5 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713634B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-bcbd69472e4d41af916ac052054b1c80 |
| 출처 메모 | uspto-grants-2004_03 |