2,3-Dichlorobenzoic acid → 2,3-dichloro-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide

반응식

[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:12]1([CH2:15][CH:16]([C:19]2[CH:20]=[N:21][C:22]([CH:25]([F:27])[F:26])=[CH:23][CH:24]=2)[CH2:17][NH2:18])[CH2:14][CH2:13]1>>[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:18][CH2:17][CH:16]([C:19]1[CH:20]=[N:21][C:22]([CH:25]([F:27])[F:26])=[CH:23][CH:24]=1)[CH2:15][CH:12]1[CH2:13][CH2:14]1)=[O:6]

참가 물질

반응물 2

HCID 57652,3-Dichlorobenzoic acid

HCID 867164003-Cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine

생성물 1

HCID 867164012,3-dichloro-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide

실험 절차

From 2,3-dichlorobenzoic acid and 3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine. LCMS (MH+): m/z=399.1, tR (minutes, Method G)=2.57

출처 및 근거

ORD 기록: ord-796c2346880b4d04976f8430e5a78171
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09102591B2

반응 노트

불러오는 중…