2-Chloro-3-methoxybenzoic acid → 2-chloro-3-methoxy-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide

반응식

[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:13]1([CH2:16][CH:17]([C:20]2[CH:21]=[N:22][C:23]([CH:26]([F:28])[F:27])=[CH:24][CH:25]=2)[CH2:18][NH2:19])[CH2:15][CH2:14]1>>[Cl:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:19][CH2:18][CH:17]([C:20]1[CH:21]=[N:22][C:23]([CH:26]([F:28])[F:27])=[CH:24][CH:25]=1)[CH2:16][CH:13]1[CH2:14][CH2:15]1)=[O:6]

참가 물질

반응물 2

HCID 162180632-Chloro-3-methoxybenzoic acid

HCID 867164003-Cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine

생성물 1

HCID 867164032-chloro-3-methoxy-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide

실험 절차

From 2-chloro-3-methoxybenzoic acid and 3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine. LCMS (MH+): m/z=395.1, tR (minutes, Method F)=2.96

출처 및 근거

ORD 기록: ord-6be8b847e55f4b27949a7fe3c314015a
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09102591B2

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