2-Chlorobenzoic Acid → 2-Chloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)benzamide

HRID 512386노트

반응식

HRID 512386 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:11][CH:12]([F:29])[C:13]1[N:18]=[CH:17][C:16]([C:19]2([CH2:27][NH2:28])[CH2:24][CH2:23][C:22]([F:26])([F:25])[CH2:21][CH2:20]2)=[CH:15][N:14]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:28][CH2:27][C:19]1([C:16]2[CH:15]=[N:14][C:13]([CH:12]([F:29])[F:11])=[N:18][CH:17]=2)[CH2:24][CH2:23][C:22]([F:25])([F:26])[CH2:21][CH2:20]1)=[O:6]

참가 물질

3

반응물 2

HCID 83742-Chlorobenzoic AcidHCID 86716443(1-(2-(Difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine

생성물 1

HCID 867164442-Chloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)benzamide

실험 절차

From 2-chlorobenzoic acid and (1-(2-(difluoro methyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine. LCMS (MH+): m/z=416.1, tR (minutes, Method F)=2.83

출처 및 근거

ORD 기록
ord-9afe5ebbb02e4f79a4e381c2746723bd
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102591B2

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