(2,3-Dimethoxyphenyl)(4-pyridinyl)methanol → (2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

HRID 51248

반응식

HRID 51248 반응식
[OH:1][CH:2]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[O:11][CH3:12]>N1C=CC=CC=1>[OH:1][CH:2]([CH:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1)[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[O:11][CH3:12]

참가 물질

3

반응물 1

HCID 314742(2,3-Dimethoxyphenyl)(4-pyridinyl)methanol

생성물 1

HCID 10890362(2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In Scheme N, step b, the pyridine functionality of 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]pyridine (10) is reduced to give 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]piperidine (11) as described previously in Scheme F, step e.

출처 및 근거

ORD 기록
ord-305ca315bbaa4e218e6ae3bd460c0e67
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713627B2

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