Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Trifluoromethyl)pyridine-4-boronic acid → 1-[1-(4-Cyano-phenyl)-ethyl]-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Trifluoromethyl)pyridine-4-boronic acid | HCID 45158880 | — |
| 반응물 | 1-(4-Cyano-benzyl)-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711527 | — |
| 반응물 | 5-Bromo-1-(4-cyano-benzyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711528 | — |
| 반응물 | 5-Bromo-1-[1-(4-cyano-phenyl)-ethyl]-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711530 | — |
| 생성물 | 1-[1-(4-Cyano-phenyl)-ethyl]-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid | HCID 86711531 | — |
반응 단계
Preparation 4 is prepared following the procedure described for preparation 1d, substituting 3-(trifluoromethyl)phenylboronic acid with 2-(trifluoromethyl)pyridine-4-boronic acid and substituting preparation 1c with preparation 2b as starting material. ESI mass spectrum: [M+H]+=428; Retention time HPLC: 0.99 min (Z018_S04).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102624B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-cd409417a5054a9d81a2c873f0f2f97a |
| 출처 메모 | uspto-grants-2015_08 |