1-Naphthyl Isothiocyanate → 5-Amino-2-(naphthalen-1-ylamino)thiazole-4-carboxamide

HRID 512524

반응식

HRID 512524 반응식
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([NH2:5])=[O:4].[N:8]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1)=[C:9]=[S:10]>CCOC(C)=O>[NH2:7][C:6]1[S:10][C:9]([NH:8][C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)=[N:1][C:2]=1[C:3]([NH2:5])=[O:4]

참가 물질

4

반응물 2

HCID 110801-Naphthyl IsothiocyanateHCID 983412-Amino-2-cyanoacetamide

생성물 1

HCID 867033685-Amino-2-(naphthalen-1-ylamino)thiazole-4-carboxamide수율 48.7%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a suspension of 2-amino-2-cyanoacetamide (0.25 g, 2.53 mmol) in EtOAc (8 mL), was added 1-isothiocyanatonaphthalene (0.467 g, 2.53 mmol), and the mixture was refluxed for 30 min. The solvent was evaporated under reduced pressure, and the resulting crude residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.35 g (48% yield) of the titled compound.

후처리

  1. temperaturethe mixture was refluxed for 30 min
  2. customThe solvent was evaporated under reduced pressure
  3. customthe resulting crude residue was purified by silica gel column chromatography
  4. washeluted with 2% MeOH in DCM

출처 및 근거

ORD 기록
ord-f4cf05c10fd2464ba09c7430bbfd55e5
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102637B2

연결된 노트

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